supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Linoleic Acid
drug:
Epoprostenol
Research Papers that Mention the Interaction
“It was concluded that linoleic acid impedes the ability of the endothelial cells to produce prostacyclin and cGMP, and to inhibit platelet aggregation.”
“We found that among these fatty acids, linoleic acid reduced the thrombin-stimulated prostacyclin release by 30-60%, oleic acid by 10-30%, whereas palmitic acid had no effect.”
Effects of free fatty acids found increased in women who develop pre-eclampsia on the ability of endothelial cells to produce prostacyclin, cGMP and inhibit platelet aggregation.“Thus, our study suggests that an increase in the intake of linoleic acid from 4.8 to 7.6 en% decreases PGI2 and PGE2 synthesis by human endothelial cells, and supplementation of the diet with linoleic acid has a longer period of effectiveness than its decrease in the diet.”
“Some reduction in PGI2 release was noted as early as 1 h after exposure to linoleic acid.”
“This suggests that linoleic acid may act as an inhibitor of PGI2 production.”
“ LA at 0.1-5 μmol/L attenuated bradykinin (BK)-induced NO and PGI2 production while suppressing the BK-induced Ca(2+) response dose-dependently.”
Linoleic acid attenuates endothelium-derived relaxing factor production by suppressing cAMP-hydrolyzing phosphodiesterase activity.“The capacity of cultured bovine pulmonary vein and aortic endothelial cells to convert extracellular arachidonic acid Into PGI2 also was reduced by about 50% when the growth medium was supplemented with linoleic acid.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback