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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Linoleic Acid and Epoprostenol

Research Papers that Mention the Interaction

It was concluded that linoleic acid impedes the ability of the endothelial cells to produce prostacyclin and cGMP, and to inhibit platelet aggregation.
We found that among these fatty acids, linoleic acid reduced the thrombin-stimulated prostacyclin release by 30-60%, oleic acid by 10-30%, whereas palmitic acid had no effect.
Scandinavian journal of clinical and laboratory investigation  •  1994  |  View Paper
Thus, our study suggests that an increase in the intake of linoleic acid from 4.8 to 7.6 en% decreases PGI2 and PGE2 synthesis by human endothelial cells, and supplementation of the diet with linoleic acid has a longer period of effectiveness than its decrease in the diet.
Journal of the American College of Nutrition  •  1991  |  View Paper
Some reduction in PGI2 release was noted as early as 1 h after exposure to linoleic acid.
This suggests that linoleic acid may act as an inhibitor of PGI2 production.
The Journal of clinical investigation  •  1980  |  View Paper
LA at 0.1-5 μmol/L attenuated bradykinin (BK)-induced NO and PGI2 production while suppressing the BK-induced Ca(2+) response dose-dependently.
Circulation journal : official journal of the Japanese Circulation Society  •  2013  |  View Paper
The capacity of cultured bovine pulmonary vein and aortic endothelial cells to convert extracellular arachidonic acid Into PGI2 also was reduced by about 50% when the growth medium was supplemented with linoleic acid.
Arteriosclerosis  •  1982  |  View Paper