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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Linoleic Acid
supplement:
Eicosatrienoic Acid
Research Papers that Mention the Interaction
“The metabolism of linoleic acid seems to be disturbed with increased proportions of dihomo-gamma linolenic acid (20 : 3 n-6) and a reduced activity of the Δ5 desaturase, while the activities of the Δ9 and Δ6 desaturases appear to be increased.”
Dietary fat and insulin action in humans“The ratio linoleic acid/dihomo-gamma-linolenic acid , reflecting the delta 6-desaturation and the following elongation step, increased with rising linoleic acid values.”
“A diet providing a large amount of linoleic acid (14% of the total caloric intake) resulted in low levels of dihomo-gamma-linolenic acid (C20:3 omega 6) and arachidonic acid (C20:4 omega 6) in serum phospholipids and cholesteryl esters.”
“Stearic acid, a long-chain saturate, does not produce any reduction, whereas eicosatrienoic acid is an even more effective inhibitor than linoleic acid.”
“The conversion of linoleic into γ-linolenic acid and eicosatrienoic into arachidonic acid were mutually inhibited and the inhibition depended on the concentration of the fatty acids incubated.”
Reciprocal interactions in the desaturation of linoleic acid into γ-linolenic and eicosa-8,11,14-trienoic into arachidonic“However, the desaturation of eicosa-8,11,14-trienoic acid is strongly enhanced by linoleic and γ-linolenic acids which may account for its non-accumulation in tissue lipids.”
“Daily supplementation of either linoleic acid or linolenic acid were effective in suppressing the synthesis of 5,8,11-eicosatrienoic acid.”
“The conversion of linoleic into 3' -linolenic acid and eicosatrienoic i n t o arachidonic acid were mutually inhibited and the inhibi t ion depended on the concentration of the fatty acids incubated.”
Determination of double bond position in polyunsaturated fatty acids using combination gas chromatography mass spectrometry“Supplementation of the essential fatty acid-deficient diet with linoleic acid caused a rapid loss of eicosatrienoic acid and palmitic acid with a concomitant increase in stearic acid and arachidonic acid.”
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