Possible Interaction: Linoleic Acid and Docosahexaenoic Acid

“Another study of that era also noted that dietary fatty acids can alter brain fatty acid composition in a time-dependent manner and that brain DHA can be derived from dietary precursor ALA, but noted that high linoleic acid intake can indeed moderately reduce brain DHA levels (Rathbone 1965).”

“Flow cytometric analysis showed that DHA treated cells either alone or in combination with LA + E2 induced marked G1/S and G2/M arrest of the cells, suggesting the inhibitory effect of DHA at this phase of cell cycle.”

“Since omega-3 … acid, DHA ) is known to block the … omega-6 polyunsaturated fatty acid ( LA ), we wanted to see whether addition of DHA can inhibit the growth of MCF-7 cells which … LA + E2 and any alteration of BRCA1 mRNA expression could be seen in DHA treated culture.”

“ DHA enrichment of the diet resulted in a significant 10-fold increase of the DHA liver content and ω-6 PUFA reducing (in particular of linoleic acid in 2.7-fold).”

“In contrast, similar concentrations of EPA and DHA had no effect on biohydrogenation of LA by mixed digesta, while the addition of LA prevented metabolism of EPA and DHA.”

“As a result, DHA suppressed the oxidation of LA , while DHA was not significantly oxidized.”