Possible Interaction: Linoleic Acid and Calcium Supplement

“Four weeks of administration of the linoleic acid produced a significant decrease in leucocyte calcium (P<0.05).”

“Osteoporosis is a significant health concern for the elderly; conjugated linoleic acid (CLA) has been shown to improve overall bone mass when calcium is included as a co-supplement.”

“The purpose of this study was to determine how dietary calcium modulates the effects of conjugated linoleic acid (CLA) in preventing bone loss, using an ovariectomised mouse model.”

“Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism.”

“Conclusion: LA stimulated cell proliferation via Ca2+ , PLC/PKC, PI3K/Akt, and p44/42 MAPKs signaling pathways in mouse ES cells.”

“These results suggest that linoleic acid stimulates Ca2+ release from intracellular Ca2+ stores and inhibits VDCC currents in rat pancreatic beta-cells via Ca2+ -induced inactivation of VDCC.”

“Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism.”

“Numerous studies have indicated that conjugated linoleic acid (CLA) positively influences calcium and bone metabolism.”

“ LA exposure increased intracellular calcium , nitric oxide, and tetrahydrodiopterin levels as well as the expression of E-selectin.”

“Our data suggest that the proinflammatory effects of LA can be mediated through calcium and peroxynitrite signaling.”

“Cytoplasmic free calcium concentration in the HLA group was significantly lower than in other groups.”

“We demonstrated previously that products of linoleic and arachidonic acids, arising from enzymatic or non-enzymatic oxidation, inhibit ATP-dependent calcium accumulation into and promote release of calcium from vesicles derived from sarcoplasmic reticulum of guinea-pig heart.”