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“The other factor that contributes to the decrease in arachidonic acid is that high concentrations of linoleic acid reduce the incorporation of arachidonate into cellular phospholipids.”
The Journal of clinical investigation • 1981 | View Paper
“Dietary fat + TYA (an analogue of arachidonate that inhibits normal metabolism of linoleic acid ) prevented the fat-dependent lowering of G6PD and 6PGD activity, synthesis and mRNA levels.”