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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Lignans
Research Papers that Mention the Interaction
“Additionally, in three-drug combinations of lignans with the saponin digitonin and doxorubicin MDR reversal activity was even stronger enhanced.”
“In two-drug combinations of lignans with the cytotoxic doxorubicin , all lignans exhibited synergistic effects in CaCo2 cells and matairesinol, arctiin, lappaol C and lappaol F display synergistic activity in CEM/ADR 5000 cells.”
Natural lignans from Arctium lappa modulate P-glycoprotein efflux function in multidrug resistant cancer cells.“Both lignans alone had no effect on the cell cycle; however, when combined with sub-toxic doses of doxorubicin , they induced cell cycle arrest in the G2/M phase, which is typical for toxic doses of doxorubicin.”
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