Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“Preadministration of alpha-tocopherol and lidocaine prevented distinctly the structure-functional alterations induced by phenobarbital in liver microsomal membranes during postischemic period.”
“Administration of alpha-tocopherol in combination with lidocaine prevented a decrease of the rate of amidopyrine N-demethylation, the concentrations of cytochromes P-450, b5 and prevented a reduction of cytochrome P-450 affinity to aniline.”
“The combination of alpha-tocopherol with lidocaine fully prevented the decrease in N-dimethylation of amidopyrine and cytochrome P-450 and b5 concentration, and the development of destructive alterations of cytoplasmic reticulum in the unaffected rat hepatocytes.”
“The experiments on rats have shown that alpha-tocopherol and lidocaine pretreatment leads to a decrease in the level of ischemic cell necrosis in the liver.”