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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Lidocaine and Vitamin E


Vitamin E

Research Papers that Mention the Interaction

Preadministration of alpha-tocopherol and lidocaine prevented distinctly the structure-functional alterations induced by phenobarbital in liver microsomal membranes during postischemic period.
Voprosy meditsinskoi khimii  •  1990  |  View Paper
Administration of alpha-tocopherol in combination with lidocaine prevented a decrease of the rate of amidopyrine N-demethylation, the concentrations of cytochromes P-450, b5 and prevented a reduction of cytochrome P-450 affinity to aniline.
Farmakologiia i toksikologiia  •  1987  |  View Paper
The combination of alpha-tocopherol with lidocaine fully prevented the decrease in N-dimethylation of amidopyrine and cytochrome P-450 and b5 concentration, and the development of destructive alterations of cytoplasmic reticulum in the unaffected rat hepatocytes.
The experiments on rats have shown that alpha-tocopherol and lidocaine pretreatment leads to a decrease in the level of ischemic cell necrosis in the liver.
Biulleten' eksperimental'noi biologii i meditsiny  •  1987  |  View Paper