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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Lidocaine , a local anesthetic, inhibited both enhanced O2- generation and tyrosine phosphorylation of a 115 kDa protein in a concentration- and time-dependent manner.”
“These results suggest that lidocaine inhibits the priming step of neutrophil activation and that it is linked to the inhibition of tyrosine phosphorylation of a 115 kDa protein.”
Lidocaine inhibits priming and protein tyrosine phosphorylation of human peripheral neutrophils.“Adding L-tyrosine to lidocaine preparations showed greater duration of cutaneous analgesia compared with lidocaine alone.”
“ Lidocaine co-administered with L-tyrosine exhibited an additive effect on infiltrative cutaneous analgesia.”
“Our pre-clinical study demonstrated that L-tyrosine elicits the local/cutaneous analgesia, and the interaction between L-tyrosine and lidocaine is additive.”
Subcutaneous L-tyrosine elicits cutaneous analgesia in response to local skin pinprick in rats.“ Lidocaine induced a concentration-related increase in tyrosine phosphorylation of the 125-kDa band corresponding to PP125FAK phosphorylation (EC50 value=0.39+/-0.09 microM, maximal effect=169+/-28% of control, P<0.001).”
“ Lignocaine … tyrosine phosphorylation of IR‐β to 12.6±5.7% (P<0.001), and IRS‐1 to 32.1±18.8% (P<0.01), and …‐stimulated binding of IRS‐1 to p85 to 27.4±12.7% (P<0.001) relative to control (100%) in muscle in vivo.”
“The in vitro study revealed that lignocaine directly inhibited both basal and insulin‐stimulated tyrosine phosphorylation of IR.”
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