Possible Interaction: Lidocaine and Sodium Bicarbonate

“However, sodium bicarbonate (NaHCO3) used to transform lidocaine hydrochloride ( L-HCl ) to lidocaine base induces a pH increase that could be irritating for mucosa in the case of cuff rupture.”

“We conclude that the addition of sodium bicarbonate to lidocaine enhances the depth of epidural blockade, increases inhibition of temporal summation, and hastens the onset of block.”

“The addition of sodium bicarbonate to 2% lidocaine decreases the pain associated with an intradermal skin wheal, and although the use of a 30-gauge needle decreases the pain of injection, the addition of sodium bicarbonate seems to have a greater overall effect than needle size.”

“Buffering lidocaine with sodium bicarbonate significantly reduced pain scores reported by 46 women who participated in this randomized, double-blind study.”

“ Lidocaine plus NaHCO3 caused significantly less pain on skin infiltration (median VAS = 4; range = 0 to 51) than did lidocaine alone (VAS = 8; range = 0 to 48; p < 0.008).”

“Modification of the pH of lignocaine solutions by the addition of sodium bicarbonate is a simple method significantly to reduce the discomfort caused by the infiltration of the local anaesthetic.”

“Conclusion: Lidocaine buffered with sodium bicarbonate injected before lymphoscintigraphy significantly reduces pain experienced by the patient and improves nuclear medicine technologist satisfaction in performing the procedure.”

“SLN identification rates for each group were: 96% for the standard of care, 97% for sodium bicarbonate, 90% for 1% lidocaine, and 90% for sodium bicarbonate plus 1% lidocaine group (p=0.56).”

“We have found that the pain usually associated with intradermal injection of lidocaine is attenuated by the addition of sodium bicarbonate.”

“Neutralization of acidic 0-5";, lignocaine pH 4-7 by ihc addition of sodium bicarbonate reduced the discumfort in 14 (44%) of our patients, hut the results were not statistically significant.”