Possible Interaction: Lidocaine and Methionine

“ Lidocaine (10 microM) effectively reduced the peak Na currents in M myocytes, but had little affect on the current-voltage curve in N myocytes.”

“2 Amlodipine (0.5–2 × 10−4 M), … M), diltiazem (1–8 × 10−4 M), lignocaine (0.1–2 × 10−3 M) and cobalt (2–… order of potency, but not nifedipine (1–5 × 10−3 M ), increased the latency and inhibited, then abolished, … potentials in a concentration‐dependent manner.”

“This plateau value j infinity min, 0.9 +/- 0.09 M +/- S.E.M.) in control conditions, was decreased by lidocaine in a dose-dependent way with a Km of 388 microM. The time constant of the recovery from slow inactivation was significantly reduced by lidocaine.”

“ Lidocaine and tetracaine also inhibited radioligand binding to … K 1 values of 5.25 × 10 −4 M and 4.85 × 10 −5 M for the α-receptor and 8.2 × 10 t-5 … 6.94 × 10 −6 M for the muscarinic receptor; these inhibitions also appeared to be competitive.”

“… lidocaine and MEGX was not reversed by excess calcium, 2.2 and 4.4 mM, … cocaine, 3 × 10−6 M. Lidocaine, 5 × 10−4 M, and MEGX, 2 × 10−3 M , shifted the dose–response curve of NE to the … × 10−4 M, shifted the curve to the left.”

“ Lidocaine at 4.0 × 10-5 M produced a marked shortening of the APD in the entire voltage range.”