Possible Interaction: Lidocaine and Calcium Supplement

“ Lignocaine appears to alter the uptake of calcium by myocardial sarcoplasmic reticulum, and this may explain the negative inotropic effect of large doses.”

“ Lidocaine , cadmium, verapamil and capsaicin showed unspecific blocking effects on calcium and tetrodotoxin-resistant potentials.”

“Ranolazine and lidocaine (10 μM) similarly reduced Ca2+i overload and improved left ventricle work recovery in whole-heart models of IR injury or exposure to ouabain (80 μM).”

“ Lidocaine , by inhibiting the increase of intracellular calcium , also inhibited p38 MAPK activation and attenuated the production of proinflammatory cytokines (including TNF-&agr;, IL-1&bgr;, and IL-6), which were triggered by extracellular ATP in cultured rat microglia.”

“… calcium concentration resulted in a greater positive inotropic effect in the control (199 ± 11% of baseline) and mepivacaine groups (197 ± 22% of baseline) when compared … the lidocaine group (163 ± 19% of baseline, P < 0.05 vs. lidocaine and control groups), suggesting an impairment on intracellular Ca2+ handling by lidocaine.”

“ Calcium ions added directly to the mast cell incubation medium exert also protective effect against the action of LC.”

“On the base of our experiments and also on other reports [2, 4] it seems that LC is bound to membrane phospholipids and that it blocks the receptor for calcium which is necessery for release.”

“These data indicate that calcium ions play an important role in the LC-effect on histamine release and that there is an antagonism between calcium ions and LC.”

“Nifedipine and lidocaine decreased contractile and relaxation responsiveness to phasic [Ca2+], cumulative Ca2+, and net Ca2+ flux.”

“Blockade of voltage-gated channel-mediated Na+ entry with tetrodotoxin (1 microM) or lidocaine (200 microM) significantly reduced excess intraneuronal Na and Ca accumulation in all compartments and decreased respective K loss.”

“Furthermore, after 360 minutes of continuous coronary perfusion, the cardiac function were measured in Group … Group C. RESULTS AND CONCLUSIONS Lidocaine cardioplegia showed a good recovery of cardiac function, because lidocaine induced prompt cardiac arrest by … influx and inhibited the intracellular calcium overload by the following … sodium-calcium channels.”

“ Lidocaine (</=100 microM) inhibited the TRH-induced increase in [ Ca++ ] but failed to block either the GTP-gamma-S-induced increase in I(K), the activation of I(K) by directly elevated [Ca++] (ca.”