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Last Updated: 3 years ago

Possible Interaction: Lidocaine and Calcium Supplement

Research Papers that Mention the Interaction

Lignocaine appears to alter the uptake of calcium by myocardial sarcoplasmic reticulum, and this may explain the negative inotropic effect of large doses.
British medical journal  •  1969  |  View Paper
Lidocaine , cadmium, verapamil and capsaicin showed unspecific blocking effects on calcium and tetrodotoxin-resistant potentials.
Neuroscience  •  1995  |  View Paper
Ranolazine and lidocaine (10 μM) similarly reduced Ca2+i overload and improved left ventricle work recovery in whole-heart models of IR injury or exposure to ouabain (80 μM).
Journal of Pharmacology and Experimental Therapeutics  •  2012  |  View Paper
Lidocaine , by inhibiting the increase of intracellular calcium , also inhibited p38 MAPK activation and attenuated the production of proinflammatory cytokines (including TNF-&agr;, IL-1&bgr;, and IL-6), which were triggered by extracellular ATP in cultured rat microglia.
Anesthesia and analgesia  •  2010  |  View Paper
calcium concentration resulted in a greater positive inotropic effect in the control (199 ± 11% of baseline) and mepivacaine groups (197 ± 22% of baseline) when compared … the lidocaine group (163 ± 19% of baseline, P < 0.05 vs. lidocaine and control groups), suggesting an impairment on intracellular Ca2+ handling by lidocaine.
European journal of anaesthesiology  •  2007  |  View Paper
Calcium ions added directly to the mast cell incubation medium exert also protective effect against the action of LC.
On the base of our experiments and also on other reports [2, 4] it seems that LC is bound to membrane phospholipids and that it blocks the receptor for calcium which is necessery for release.
These data indicate that calcium ions play an important role in the LC-effect on histamine release and that there is an antagonism between calcium ions and LC.
Agents and Actions  •  2005  |  View Paper
Nifedipine and lidocaine decreased contractile and relaxation responsiveness to phasic [Ca2+], cumulative Ca2+, and net Ca2+ flux.
Journal of cardiovascular pharmacology  •  2003  |  View Paper
Blockade of voltage-gated channel-mediated Na+ entry with tetrodotoxin (1 microM) or lidocaine (200 microM) significantly reduced excess intraneuronal Na and Ca accumulation in all compartments and decreased respective K loss.
Neuroscience  •  2001  |  View Paper
Furthermore, after 360 minutes of continuous coronary perfusion, the cardiac function were measured in Group … Group C. RESULTS AND CONCLUSIONS Lidocaine cardioplegia showed a good recovery of cardiac function, because lidocaine induced prompt cardiac arrest by … influx and inhibited the intracellular calcium overload by the following … sodium-calcium channels.
The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi  •  2000  |  View Paper
Lidocaine (</=100 microM) inhibited the TRH-induced increase in [ Ca++ ] but failed to block either the GTP-gamma-S-induced increase in I(K), the activation of I(K) by directly elevated [Ca++] (ca.
Molecular pharmacology  •  1999  |  View Paper
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