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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Licorice
drug:
Paclitaxel
Research Papers that Mention the Interaction
“ Glycyrrhizae Radix , Rhei Rhizoma, Scutellariae Radix, Poria, Zizyphi Fructus, Zingiberis Rhizoma (dry), Coptidis Rhizoma, … Herba and Asiasari Radix significantly enhanced the sensitivity to a MDR1 substrate paclitaxel , whereas none of the herbal extracts used had any effect on … sensitivity to 5-fluorouracil, which is not a substrate for MDR1.”
Effects of 19 herbal extracts on the sensitivity to paclitaxel or 5-fluorouracil in HeLa cells.“However, the herb–drug interaction between licorice and paclitaxel is still unknown.”
“Results The results … pretreatment of licorice could decrease the area under the curve (AUC 0– t ) (from 7483.08 ± 528.78 to 6679.12 ± 266.56 mg/….01), and increase the total clearance (CL) (from 0.36 ± 0.02 to 0.39 ± 0.02 L/h/kg) of paclitaxel ( …).”
Herb–Drug Interaction Potential of Licorice Extract and Paclitaxel: A Pharmacokinetic Study in Rats
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