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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Levofloxacin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“RESULTS There was no significant interaction in healthy volunteers, however, when cystic fibrosis patients were given le ofloxacin wi th 2-h spaced cal cium, t he maximum plasma concentration (Cmax) decreased by 19% and time to Cmax increased by 37% (p<0.05).”
Altered steady state pharmacokinetics of levofloxacin in adult cystic fibrosis patients receiving calcium carbonate.“Interestingly, Ca2+ and Mg2+ inhibited levofloxacin uptake in a concentration-dependent manner.”
“ Levofloxacin … Ca2+ -depleted, EGTA-containing medium by approximately 33% (P = 0.022), while Ni2+, a Ca2+ channel inhibitor, inhibited it in a concentration-dependent manner, with … approximately 2.65 mM. Verapamil (anl-type Ca2+ channel inhibitor) and other pharmacologic agents which modify Ca2+ homeostasis did not modify levofloxacin uptake.”
“Introduction Oral antimicrobials, including ciprofloxacin, levofloxacin and doxycycline, are susceptible to binding with enteral therapies such as calcium and iron therapies.”
Burden of enteral supplement interactions with common antimicrobial agents: a single-centre observational analysis
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