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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Previous reports have indicated that ascorbic acid (AsA) can reduce LD dosage without losing its effectiveness.”
The Effect of Ascorbic Acid on the Pharmacokinetics of Levodopa in Elderly Patients with Parkinson Disease“ Ascorbic acid therapy reduced plasma concentrations of levodopa and 3-O-methyldopa but did not alter erythrocyte COMT activity.”
“To reduce hydrogen peroxide production due to MAO activity, a combined treatment of L-dopa plus a selective MAO inhibitor and eventually additional administration of radical scavengers ( ascorbic acid , vitamin E etc.)”
“ Ascorbic acid (200 microM) protected the cells from the effects of L-dopa ; ascorbate alone enhanced pyruvate but not succinate oxidation.”
“Our results indicate that ascorbic acid and deprenyl prevent levodopa neurotoxicity by unrelated mechanisms.”
“Tocopherol, 23 or 115 × 10−6 M, lacks significant preventive effect on levodopa toxicity, but ascorbic acid , 10−3 M, prevents levodopa toxicity and quinone formation.”
“Furthermore, pretreatment with ascorbic acid (400 mg/kg) or deprenyl (2 mg/kg) prevented the l-dopa –induced decreases in 5-HT neurons.”
“In addition, 5-HT content was decreased significantly in the DRN and prefrontal cortex by l-dopa treatment, effects that were prevented by ascorbic acid pretreatment.”
Chronic l-Dopa Decreases Serotonin Neurons in a Subregion of the Dorsal Raphe Nucleus“ Ascorbic acid , at the concentration found in glia conditioned medium, provided partial protective effect against L-DOPA toxicity.”
“ Ascorbic acid (200 microM), an agent that suppresses the autoxidation of L-DOPA and dopamine, blocked the anti-catalase effect of L-DOPA, but not that of dopamine.”
“Although vitamin C and deprenyl did not alter complex I activity, they did prevent the inhibitory effect of both levodopa and dopamine on complex I activity.”
“In sharp contrast, however, when ascorbic acid was also added, L-DOPA no longer suppressed LPO; indeed, L-DOPA stimulated LPO in the presence of added iron and ascorbic acid.”
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