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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Levodopa
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“ Pyridoxine may augment the conversion of levodopa to dopamine in the periphery and therefore decrease availability of levodopa to the brain.”
Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease“ Pyridoxine , a co-factor in the decarboxylation of dopa, reverses the movement disorder of l-dopa intoxication.”
“A decrease by pyridoxine in the efficacy of levodopa used in the treatment of Parkinsonism is an example.”
“It is suggested that the compound under discussion is a competitive antagonist of L-DOPA , when the latter is involved in reactions with pyridoxal phosphate.”
“The administration of pyridoxine has been reported to have reduced the anti-Parkinsonian effectiveness of a given dose of L-dopa.'”
“The interaction of levodopa and vitamin B6 is a well-known issue.”
“The results indicated that a vitamin B6 intake level of more than 50 mg/day could reduce the efficacy of levodopa.”
“We searched two databases (PubMed and "Igaku Chuo Zasshi") for articles about adverse events due to the interaction of levodopa and vitamin B6 published up to August 2017.”
“ Pyridoxine (Vitamin B6) may rapidly minimise or negate the effects of levodopa in Parkinsonism by enhancing its extracerebral metabolism.”
“A small proportion of patients receiving L-dopa therapy were found to have a CSF PLP concentration below the appropriate reference range.”
“Renal clearance of acidic drugs such as acetylsalicylic acid and barbituric acid, which is impaired at high age, is further reduced by high doses of vitamin C. Vitamin B6 reduces the therapeutic effect of L-dopa.”
“ L-Dopa induced a statistically significant suppression of TRH, caused PRL release; such suppression appears to be lower when TRH plus pyridoxine were administered simultaneously.”
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