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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Levodopa
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“This suggests evaluating whether vitamin B12 deficit could aggravate the PD in patients under Levodopa therapy by impairing S-adenosylmethionine synthesis in substantia nigra.”
“ Levodopa gel infusion may induce a decrease in vitamin B12 levels, leading to peripheral neuropathy.”
Polyneuropathy while on duodenal levodopa infusion in Parkinson’s disease patients: we must be alert“ Levodopa elevates tHcy and lowers vitamin B12 concentration to modest degrees.”
“This may lead to hypomethylation of essential neural components, and might explain the neuropsychiatric symptoms in folate and vitamin B12 deficiency.5 This mechanism may contribute to side effects of levodopa.”
“ Cyanocobalamin correlated with L-Dopa daily dose (r = −0.287, p < 0.05) and L-Dopa duration of administration (r = −0.316, p < 0.05).”
“The results imply that longer exposure to high doses of L-Dopa may cause vitamin B12 and folate imbalance and PNP, secondarily.”
Large-Fiber Neuropathy in Parkinson’s Disease: Clinical, Biological, and Electroneurographic Assessment of a Romanian Cohort
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