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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Levodopa
supplement:
Tryptophan
Research Papers that Mention the Interaction
“ Levodopa produced a striking improvement in the ratings of tremor, rigidity, akinesia, gait, and posture equally in patients treated with this compound alone or in combination with L-tryptophan.”
“Tests of functional ability to do certain tasks tended to improve in all patients but showed a significant improvement only in patients treated by the combination of levodopa and L-tryptophan.”
Levodopa and L-tryptophan therapy in Parkinsonism.“ L-DOPA (100 mg/kg) decreased the binding of serotonin formed from tryptophane (100 mg/kg), accelerating its catabolism in the brain; at the same time 1-DOPA eliminated the depressive action of tryptophane on the emotional reactivity and aggressiveness.”
“It has been found that l-tryptophane depresses while l-Dopa intensifies emotional reactivity and aggressiveness, the latter lowering the level of endogenous serotonin and enhancing its catabolism.”
“ L-Dopa , dl-amphetamine, alpha-methyl-Dopa, parachlorophenylalanine and serotonino-blockators--deseryl and lysergide--eliminate the tranquilizing action of tryptophane on emotional reactivity, decreasing serotonin accumulation and intensifying the formation of 5-oxyindolacetic acid.”
“The tryptophan , 5-hydroxyindolacetic acid (5-HIAA), and 3-OH kynurenine concentrations had significant positive correlations with L-dopa doses.”
“and oral Try medication, and in one case a regeneration of the ability to absorb Try during levodopa treatment was noted.”
“Further, synthesis of DA from l-DOPA was decreased in the presence of the amino acids tyrosine, phenylalanine and tryptophan , whereas the amino acids glycine and proline were without any significant effect.”
Uptake and decarboxylation of L-3,4-dihydroxyphenylalanine in cultured monkey placenta amniotic epithelial cells.“ L-DOPA increased nocturnal levels of Gly, Thr, Trp , and Val but had no effect on the daytime amino acids content.”
“Single administration of l-tryptophane and L-DOPA decreased, and 5-day administration of the both preparations potentiated the inhibitory action of dexamethazone.”
“After the simultaneous injection of L-DOPA and L-tryptophan , cross-influence on the turnover of 5-HT and dopamine is noted, while in behaviour the effects of L-DOPA prevail over those of L-tryptophan.”
“As expected, levodopa alone reduced tryptophan and serotonin and increased dopa and dopamine at the 1 and 2 hour intervals.”
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