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Last Updated: 2 years ago

Possible Interaction: Levodopa and Tryptophan

supplement:

Tryptophan

Research Papers that Mention the Interaction

Levodopa produced a striking improvement in the ratings of tremor, rigidity, akinesia, gait, and posture equally in patients treated with this compound alone or in combination with L-tryptophan.
Tests of functional ability to do certain tasks tended to improve in all patients but showed a significant improvement only in patients treated by the combination of levodopa and L-tryptophan.
Lancet  •  1972  |  View Paper
L-DOPA (100 mg/kg) decreased the binding of serotonin formed from tryptophane (100 mg/kg), accelerating its catabolism in the brain; at the same time 1-DOPA eliminated the depressive action of tryptophane on the emotional reactivity and aggressiveness.
Biulleten' eksperimental'noi biologii i meditsiny  •  1976  |  View Paper
It has been found that l-tryptophane depresses while l-Dopa intensifies emotional reactivity and aggressiveness, the latter lowering the level of endogenous serotonin and enhancing its catabolism.
L-Dopa , dl-amphetamine, alpha-methyl-Dopa, parachlorophenylalanine and serotonino-blockators--deseryl and lysergide--eliminate the tranquilizing action of tryptophane on emotional reactivity, decreasing serotonin accumulation and intensifying the formation of 5-oxyindolacetic acid.
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova  •  1975  |  View Paper
The tryptophan , 5-hydroxyindolacetic acid (5-HIAA), and 3-OH kynurenine concentrations had significant positive correlations with L-dopa doses.
Neuroscience Letters  •  1993  |  View Paper
and oral Try medication, and in one case a regeneration of the ability to absorb Try during levodopa treatment was noted.
Acta medica Scandinavica  •  1973  |  View Paper
Further, synthesis of DA from l-DOPA was decreased in the presence of the amino acids tyrosine, phenylalanine and tryptophan , whereas the amino acids glycine and proline were without any significant effect.
Placenta  •  2007  |  View Paper
L-DOPA increased nocturnal levels of Gly, Thr, Trp , and Val but had no effect on the daytime amino acids content.
Journal of biological rhythms  •  2000  |  View Paper
Single administration of l-tryptophane and L-DOPA decreased, and 5-day administration of the both preparations potentiated the inhibitory action of dexamethazone.
Problemy endokrinologii  •  1978  |  View Paper
After the simultaneous injection of L-DOPA and L-tryptophan , cross-influence on the turnover of 5-HT and dopamine is noted, while in behaviour the effects of L-DOPA prevail over those of L-tryptophan.
Annali dell'Istituto superiore di sanita  •  1978  |  View Paper
As expected, levodopa alone reduced tryptophan and serotonin and increased dopa and dopamine at the 1 and 2 hour intervals.
Neurology  •  1975  |  View Paper
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