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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Levodopa
supplement:
Sapropterin
Research Papers that Mention the Interaction
“… (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (6R-BH4), … of L-3,4-dihydroxyphenylalanine (DOPA) measured using microdialysis under the inhibition of aromatic L-amino acid decarboxylase by NSD-1015 (in … carrying human TH gene and of non-transgenic mice, to a similar extent by about 4-fold.”
Peripherally administered (6R)-tetrahydrobiopterin increases in vivo tyrosine hydroxylase activity in the striatum measured by microdialysis both in normal mice and in transgenic mice carrying human tyrosine hydroxylase“In … that R-THBP … L-DOPA or 5-HTP possess the additive effect on the treatment of atypical phenylketonuria, Parkinsonian disease, and infantile autism, we recently found a … system; R-THBP functions as a release-promotor of dopamine, serotonin, and norepinephrine from the striatal and cortical nerve terminals1,2.”
6R-[3H]tetrahydrobiopterin binding activities in rat brain.
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