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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“In conclusion, quercetin possesses strong iron-chelating abilities and could be recommended as a disease-modifying therapy when administered in combination with L-dopa , early on in the course of Parkinson's disease.”
“ Quercetin efficiently halted the deleterious toxic effects of L-dopa , revealing normalization of catalepsy and rotarod score, in addition to amelioration of neurochemical parameters, indicating benefit of both symptomatic and neuroprotective therapies.”
In Silico and In Vivo Studies on Quercetin as Potential Anti-Parkinson Agent.“While both tea catechins and quercetin strongly inhibit human liver catechol-O-methyltransferase (COMT)-mediated O-methylation of L-DOPA in vitro, only (+)-catechin exerts a significant inhibition of L-DOPA methylation in both peripheral compartment and striatum in rats.”
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration“ Quercetin through its COMT and MAO enzyme-inhibiting properties might potentiate the anticatatonic effect of L-dopa plus carbidopa treatment.”
“When quercetin was combined with a subthreshold dose of L-dopa plus carbidopa, the anticatatonic effect was potentiated.”
“In the time course of the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by the enzyme in the presence of different concentrations of quercetin , the rate decreased with increasing time until a straight line was approached.”
Kinetics of mushroom tyrosinase inhibition by quercetin.
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