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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Levodopa
supplement:
Phenylalanine
Research Papers that Mention the Interaction
“ Phenylalanine , a large neutral amino acid (LNAA) competing with levodopa for transport across the blood-brain barrier, reduced the hypotensive and antiparkinsonian effects of levodopa.”
Pharmacodynamics of the hypotensive effect of levodopa in parkinsonian patients.“Dietary restriction of phenylalanine and oral administration of amine precursors, L-dopa and 5-hydroxytryptophan had poor efficiency on epilepsy and psychomotor delay.”
“These observations suggest that either L-dopa entry into CSFV and the brain are differentially affected by phenylalanine or that phenylalanine affects other steps in the motor response.”
“Furthermore, the clinical and biochemical effects of L-dopa were inhibited by phenylalanine and 5-HTP, respectively, demonstrating that these amino acids have antagonistic pharmacological effects.”
“High-protein meals or oral phenylalanine , leucine, or isoleucine (100 mg per kilogram of body weight) reversed the therapeutic effect of infused levodopa without reducing plasma levodopa concentrations.”
“ L-DOPA , when given with L-phenylalanine , reduced the absorption rate of this amino acid.”
“This effect was only seen when L-DOPA and L-phenylalanine were given simultaneously.”
“ L-DOPA preloading induced a massive increase of BPA concentration either in vitro on C6 glioma cells or in vivo in the animal model tumour.”
Boronophenylalanine uptake in C6 glioma model is dramatically increased by L-DOPA preloading.“Further, synthesis of DA from l-DOPA was decreased in the presence of the amino acids tyrosine, phenylalanine and tryptophan, whereas the amino acids glycine and proline were without any significant effect.”
“ L-Dopa uptake and conversion to DA was competitively inhibited by other aromatic amino acids (Tyr and Phe).”
“In presence of quassin phenylalanine , tyrosine and L-dopa levels were increased in larvae.”
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