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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The oral administration of melatonin to men has been reported to cause a rapid and significant elevation of serum GH, and to inhibit GH release after stimulation by L-Dopa.”
Lack of an effect of melatonin on the basal and L-Dopa stimulated growth hormone secretion in men“In addition, MSH potentiated (Plotnikoff et al. 1971), while melatonin (an MSH antagonist) blocked L-dopa induced dyskinesias in mice (Cotzias et al. 1971).”
“Exposure to dopamine (10 microM) or L-DOPA (100 microM) markedly diminished the forskolin-stimulated release of melatonin , as well as the production of 5-hydroxytryptophan and serotonin.”
“In addition, L-dopa increases rat pineal melatonin concentration and N-acetyl transferase activity.”
“In addition, the cortisol secretion was increased (P > 0.05), but melatonin was further inhibited after L-DOPA treatment at 6:00 (P < 0.01).”
Long-term Levodopa Treatment Accelerates the Circadian Rhythm Dysfunction in a 6-hydroxydopamine Rat Model of Parkinson's Disease“Compared with L-dopa alone, combined treatment with melatonin and L-dopa significantly improved all these sleep parameters in two animals.”
“In comparison to the parkinsonian condition, combined treatment with melatonin and L-dopa significantly increased total sleep time and sleep efficiency, and reduced the time spent awake during the night in all animals.”
“Addition of melatonin to L-dopa therapy improved the motor response to L-dopa and increased striatal dopamine level.”
“ Melatonin has blocked adventitious movements induced by L-dopa in intact mice.”
“Plasma melatonin levels were significantly associated with the levodopa equivalent daily dose (r = −0.262, P < 0.05, n = 61).”
Elevated Plasma Melatonin Levels Are Correlated With the Non-motor Symptoms in Parkinson’s Disease: A Cross-Sectional Study“When melatonin was added to the ORAC assay in combination with dopamine or L-dopa , the rate of beta-PE oxidation was decreased as well.”
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