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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Levodopa
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Chelation of iron by levodopa is the likely mechanism for this drug interaction.”
“ Iron in its ferrous state is oxidized rapidly to the ferric state in the presence of levodopa at pHs found in the small intestine.”
Ferrous sulfate reduces levodopa bioavailability: Chelation as a possible mechanism“Traces of iron can enhance the auto-oxidation of l-DOPA , in turn, generating reactive oxygen species (ROS) and consequently oxidative stress in insects.”
Assessment of oxidative stress and activities of antioxidant enzymes depicts the negative systemic effect of iron-containing fertilizers and plant phenolic compounds in the desert locust“When a levodopa or droxidopa preparation, judged as grade 3 in screening, was concomitantly administered with an iron preparation , a significant reduction in bioavailability of the test drug was observed, indicating possible drug interaction between the test drug and oral iron.”
“ FE Na+ elicited by the diuretic was enhanced 30-40% by 0.5 microM of LD (n = 5, P < 0.05), and 60-80% by LD 1 microM (n = 5, P < 0.05).”
“The average reduction in L-dopa absorption in the presence of iron was 22.6% in the duodenum and 23.9% in the jejunum.”
“Based on these results, we suggest that l-DOPA acts by two mechanisms: it influences amino acid metabolism and deregulates metal homeostasis, especially that of iron , which is required for the fundamental biological processes of all organisms.”
Microarray analysis of Arabidopsis plants in response to allelochemical l-DOPA
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