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Last Updated: 3 years ago

Possible Interaction: Levodopa and Folate

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drug:

Levodopa

supplement:

Folate

Research Papers that Mention the Interaction

“The effect of l-dopa on PP2A and p-Tau was exacerbated in cells exposed to folate deficiency.”

Acute Administration of l-Dopa Induces Changes in Methylation Metabolites, Reduced Protein Phosphatase 2A Methylation, and Hyperphosphorylation of Tau Protein in Mouse Brain

The Journal of Neuroscience • 2012 | View Paper

“This may lead to hypomethylation of essential neural components, and might explain the neuropsychiatric symptoms in folate and vitamin B12 deficiency.5 This mechanism may contribute to side effects of levodopa.”

Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD

Neurology • 2001 | View Paper

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