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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Levodopa
supplement:
Ferrous Sulfate
Research Papers that Mention the Interaction
“Persons with the highest peak levodopa levels and AUC after levodopa alone had the greatest reduction in peak levodopa levels and AUC after levodopa ingestion with ferrous sulfate.”
“When levodopa was taken with ferrous sulfate there was a 55% decrease in peak levodopa levels (3.6 ± 2.6 vs 1.6 ± 0.82 nmol/ml; p < 0.05) and a 51% decrease in AUC (257 ± 133 vs 125 ± 51 nmol · min/ml; p < 0.01).”
Ferrous sulfate reduces levodopa bioavailability: Chelation as a possible mechanism“The findings suggest that care should be exercised when simultaneous administration of either methyldopa or levodopa with ferrous sulphate is indicated.”
“ Ferrous sulfate decreases L-dopa bioavailability in humans probably as a result of binding of L-dopa by iron in the gastrointestinal tract.”
“ Ferrous sulfate resulted in a reduction in L-dopa absorption in the buffers at all pHs in both the duodenum and jejunum.”
The effect of ferrous sulfate and pH on L-dopa absorption.
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