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Last Updated: 2 years ago

Possible Interaction: Levodopa and Ferrous Sulfate


Ferrous Sulfate

Research Papers that Mention the Interaction

Persons with the highest peak levodopa levels and AUC after levodopa alone had the greatest reduction in peak levodopa levels and AUC after levodopa ingestion with ferrous sulfate.
When levodopa was taken with ferrous sulfate there was a 55% decrease in peak levodopa levels (3.6 ± 2.6 vs 1.6 ± 0.82 nmol/ml; p < 0.05) and a 51% decrease in AUC (257 ± 133 vs 125 ± 51 nmol · min/ml; p < 0.01).
Clinical pharmacology and therapeutics  •  1989  |  View Paper
The findings suggest that care should be exercised when simultaneous administration of either methyldopa or levodopa with ferrous sulphate is indicated.
The Journal of pharmacy and pharmacology  •  1990  |  View Paper
Ferrous sulfate decreases L-dopa bioavailability in humans probably as a result of binding of L-dopa by iron in the gastrointestinal tract.
Ferrous sulfate resulted in a reduction in L-dopa absorption in the buffers at all pHs in both the duodenum and jejunum.
Canadian journal of physiology and pharmacology  •  1990  |  View Paper