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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Levocarnitine
drug:
Olanzapine
Research Papers that Mention the Interaction
“Also, olanzapine markedly inhibited L-Car uptake in MDCK-hOCTN2 cells (1.06 µM of IC50), HepG2 cells and primary mouse hepatocytes.”
“Olanzapine treatment also reduced hepatic β-hydroxybutyrate level (indicator of fatty acid β-oxidation), meanwhile, the L-carnitine (L-Car) concentration in liver of olanzapine group was significantly lower than that in control group.”
“Supplementation of L-Car attenuated hepatic TG rise and improved simple steatosis in olanzapine treatment mice.”
Up-regulation of hepatic fatty acid transporters and inhibition/down-regulation of hepatic OCTN2 contribute to olanzapine-induced liver steatosis.
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