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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Leukotriene D4
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“The cholestatic effect of LTD4 was attenuated by infusion of SAMe which, at rates of 67 and 100 microg/min, totally prevented the decrease in bile salt excretion.”
“We also found that the increase in perfusion pressure induced by LTD4 was prevented by SAMe in a dose‐dependent manner.”
“We conclude that SAMe reverts the cholestatic, cytotoxic, and hemodynamic effects of LTD4 on the liver, and that these protective effects might be partly because of a stimulation of the biliary excretion of the leukotriene.”
S‐adenosyl‐L‐methionine protects the liver against the cholestatic, cytotoxic, and vasoactive effects of leukotriene D4: A study with isolated and perfused rat liver
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