Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 6 months ago

Possible Interaction: Leukotriene D4 and S-Adenosylmethionine

Research Papers that Mention the Interaction

The cholestatic effect of LTD4 was attenuated by infusion of SAMe which, at rates of 67 and 100 microg/min, totally prevented the decrease in bile salt excretion.
We also found that the increase in perfusion pressure induced by LTD4 was prevented by SAMe in a dose‐dependent manner.
We conclude that SAMe reverts the cholestatic, cytotoxic, and hemodynamic effects of LTD4 on the liver, and that these protective effects might be partly because of a stimulation of the biliary excretion of the leukotriene.
Hepatology  •  1997  |  View Paper