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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Leukotriene D4 and S-Adenosylmethionine

Research Papers that Mention the Interaction

The cholestatic effect of LTD4 was attenuated by infusion of SAMe which, at rates of 67 and 100 microg/min, totally prevented the decrease in bile salt excretion.
We also found that the increase in perfusion pressure induced by LTD4 was prevented by SAMe in a dose‐dependent manner.
We conclude that SAMe reverts the cholestatic, cytotoxic, and hemodynamic effects of LTD4 on the liver, and that these protective effects might be partly because of a stimulation of the biliary excretion of the leukotriene.
Hepatology  •  1997  |  View Paper