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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Leukotriene D4
supplement:
Genistein
Research Papers that Mention the Interaction
“In addition, pertussis toxin and genistein , both known to interfere with the LTD4-induced calcium signal, completely or partially reversed the actin-depolymerising effect of LTD4.”
The inflammatory mediator leukotriene D4 triggers a rapid reorganisation of the actin cytoskeleton in human intestinal epithelial cells.“ Genistein concentration-dependently relaxed histamine (30 microM)-, carbachol (0.2 microM)-, KCl (30 mM)- and leukotriene D4 (10 nM)-induced precontractions and inhibited cumulative histamine- and carbachol-induced contractions in a non-competitive manner.”
Relaxation of isolated guinea pig trachea by genistein via inhibition of phosphodiesterase.“ Genistein , but not tyrphostin 47, significantly suppressed bronchial contraction to leukotriene D4 at 50 microM and to histamine at 100 microM. Daidzein, an inactive congener of genistein, did not alter OA-induced anaphylactic contraction.”
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