Possible Interaction: Leukotriene D4 and Calcium Supplement

“ LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells.”

“However, in human airway smooth-muscle (HASM) cells, LTD4 , at variance with histamine, elicited only a small, transient change in intracellular calcium ion concentration.”

“When these cells were stimulated with LTD4 , intracellular calcium concentration was increased and mitogen-activated protein kinase (MAP kinase) was activated severalfold.”

“Eosinophil-differentiated cells developed mainly LTD4 receptors (Kd = 41.91 nM), and stimulation with LTD4 induced an increase in intracellular calcium that was antagonised by a specific LTD4 antagonist.”

“Incremental addition of calcium to the parenchyma in Ca++-free buffer containing LTD4 elicited greater than control LTD4-induced contraction and TxB2 generation.”