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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Leukotriene C4
supplement:
Masoprocol
Research Papers that Mention the Interaction
“Both ionophore- and Ig-induced LTC4 and LTB4 release were completely inhibited by removal of calcium from the media and by preincubation of cells with nordihydroguaiaretic acid.”
Release of leukotrienes C4 and B4 and prostaglandin E2 from human monocytes stimulated with aggregated IgG, IgA, and IgE.“Peaks that migrated with authentic standards for LTB4, LTC4 , and LTD4 were inhibited by the lipoxygenase inhibitor nordihydroguaiaretic acid.”
“Pretreatment with NDGA , CuNSN and CuCl2, protects the gastric mucosa from damages and reduces the increase in LTC4 mucosal formation.”
“These results suggest that one of the possible mechanisms of the NDGA protective effect is related to the inhibition of LTC4 formation, while the PGE2 increase in synthesis together with the leukotriene inhibition could contribute to the protective effect of CuNSN and CuCl2.”
Eicosanoid and gastroprotection by copper derivatives and NDGA“Although NDGA decreased i-LTC4 in perfusate in a dose-dependent manner, it did so at concentrations which were ten times lower than those causing inhibition of hypoxic vasoconstriction.”
“The action of NDHGA was partially counteracted by the addition of LTC4 at 10(-7) M.(ABSTRACT TRUNCATED AT 250 WORDS)”
“Azelastine and the known 5-lipoxygenase inhibitors, nordihydroguaiaretic acid and AA-861, exerted concentration-dependent inhibition of allergic LTC4 formation in chopped lung tissue from actively sensitized guinea pigs and calcium ionophore A23187-stimulated LTC4 synthesis in mixed peritoneal cells from rats.”
“In addition, in uteri from ovariectomized-estrogenized rats, incubated with indomethacin, NDGA and FPL-55712, decreased the augmenting action of indomethacin on glucose metabolism, whereas LTC4 (10(-10)-10(-7)M) evoked a complete reversal of the inhibitory influence of NDGA on the formation of 14CO2.”
“Ten microM NdgA (nordihydroguaiaretic acid) an inhibitor of lipoxygenase pathway, inhibited LTB4 and LTC4 production, increased basal level of casein secretion and inhibited PRL-stimulated casein secretion.”
“On the contrary, a combination of LTC4 (10 ng/h) and PGE2 (1 microgram/h) along with NDGA (5 micrograms/h) significantly increased the uterine weight to a level that was comparable to that induced by the infusion of the vehicle.”
“The infusion of LTC4 (10 ng/h) or PGE2 (1 microgram/h) with NDGA , at 1 and 5 micrograms/h, could not overcome its inhibitory effect on decidualization.”
“The intrauterine infusion of NDGA for 24 h inhibited the release of PGE2, PGF2 alpha, LTC4 and LTB4 as compared to those released by the vehicle-infused horns.”
“ LTC4 biosynthesis was effectively inhibited by the lipoxygenase inhibitor NDGA.”
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