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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Leukotriene B4
supplement:
Vitamin E
Research Papers that Mention the Interaction
“In ionophore-stimulated (A23187; 1–2.5 μM) human blood neutrophils or differentiated HL-60 cells, vitamin E forms differentially inhibited leukotriene B4 (LTB4) with an IC50 of 5–20 μM for γ-tocopherol, δ-tocopherol (δT), and γ-tocotrienol, but a much higher IC50 for α-tocopherol.”
Natural Forms of Vitamin E and 13′-Carboxychromanol, a Long-Chain Vitamin E Metabolite, Inhibit Leukotriene Generation from Stimulated Neutrophils by Blocking Calcium Influx and Suppressing 5-Lipoxygenase Activity, Respectively“ Vitamin E , the most important lipophilic antioxidant, prevented both membrane peroxidation and release of leukotriene B4 by inhibiting 5-lipoxygenase activity without affecting enzyme expression.”
“In the presence of AT , a significant reduction in leukotriene B4 and IL-1 beta levels was observed, which was reversed by the addition of leukotriene B4.”
“When LTB4 was used as an aggregating agent, vitamin E markedly inhibited PMN and MNL aggregation, whereas vitamin C was ineffective.”
“gammaT, but not alphaT , significantly inhibited the formation of leukotriene B4 , a potent chemotactic agent synthesized by the 5-lipoxygenase of neutrophils.”
Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats.“ alpha-Tocopherol and ASA were shown to be the most selective in inhibiting the synthesis of both the LTB4 diasteroisomers active as enhancers of rat macrophage chemotaxis.”
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