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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Leukotriene B4
supplement:
Tretinoin
Research Papers that Mention the Interaction
“ Retinoic acid exposure induced microsomal LTB4 hydroxylation activities in mouse and human skin cells.”
20-Hydroxylation is the CYP-dependent and retinoid-inducible leukotriene B4 inactivation pathway in human and mouse skin cells.“However, LTB4 synthesis was dose-dependently inhibited by incubation with retinoic acid.”
Retinoic acid stimulates peptide leukotriene-syntheses in rat basophilic leukemia-1 (RBL-1) cells.“Inhibition of the generation of LTB4 by tretinoin was confirmed by reverse phase-high pressure liquid chromatography.”
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