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Last Updated: 3 years ago
drug:
Leukotriene B4
supplement:
Quercetin
Research Papers that Mention the Interaction
“ Quercetin was a potent inhibitor of leukotriene B4 formation in leukocytes (IC50 approximately 2 microM), and its activity was dependent on specific structural features, particularly the 2,3-double bond of the C-ring.”
Metabolic transformation has a profound effect on anti-inflammatory activity of flavonoids such as quercetin: lack of association between antioxidant and lipoxygenase inhibitory activity.“ Quercetin at 1-100 microM caused concentration-dependent inhibition of LTB4 and PGE2 production.”
“The extract (25 microg/ml), rutin (25 microM) and quercetin (25 microM) inhibited LTB4 synthesis at all concentrations of A23187 used.”
“ Quercetin also reduced LTB4 synthesis in cells stimulated with ionophore A23187, either ex‐vivo or in‐vitro.”
Flavonoids, leucocyte migration and eicosanoids“Genistein, equol, quercetin , and kaempferol strongly inhibited LTB4 production without cytotoxicity.”
A new method to evaluate anti-allergic effect of food component by measuring leukotriene B4 from a mouse mast cell line
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