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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Leukotriene B4
supplement:
Progesterone
Research Papers that Mention the Interaction
“These expression profiles of LTA4 hydrolase suggest the involvement of LTB4 in luteal cell function during CL formation and early pregnancy.”
Human large luteal cells in the menstrual cycle and early pregnancy express leukotriene A4 hydrolase.“Glucocorticoids and progesterone did not affect PGE2 output by tissues; however, they greatly stimulated LTB4 production.”
“ Leukotriene B4 directly enhanced progesterone release from superfused human granulosa cells.”
“A significant inverse relationship existed between the accumulation rates of progesterone and LTB4 in the luteal cells.”
“Furthermore, the addition of LTB4 inhibited progesterone production in a dose-dependent manner in both the presence and absence of hCG.”
“In conclusion, LTB4 could be synthesized by human corpora lutea in vitro, and correlated inversely with the secretion rates of progesterone.”
“However, progesterone and a bacterial suspension of E. coli reduced the synthesis of LTB4.”
Leukotriene B4 in cows with normal calving, and in cows with retained fetal membranes and/or uterine subinvolution.
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