Possible Interaction: Leukotriene B4 and Masoprocol

“Chemotaxis and enzyme release stimulated by LTB4 and oligopeptide were inhibited by NDGA.”

“Both ionophore- and Ig-induced LTC4 and LTB4 release were completely inhibited by removal of calcium from the media and by preincubation of cells with nordihydroguaiaretic acid.”

“ Nordihydroguaiaretic acid , an inhibitor of the lipoxygenase pathway, blocked IL-8 and leukotriene B4 (LTB4 production induced by OxLA, whereas indomethacin, an inhibitor of the cyclooxygenase pathway, blocked IL-8, prostaglandin E2 (PGE2), and thromboxane B2 (TXB2) production.”

“ LTB4 induced an enhancement of aggregation in psoriasis, whereas NDGA strongly inhibited it.”

“Macrophages treated with a non‐selective 5‐lipoxygcnasc inhibitor, nordihydro‐guaiaretic acid (NDGA), used at 10 μm, added 15 min before LPS 100 ng/ml, produce a dose‐dependent inhibition of LTB4.”

“HrIL-1ra used at 15 ng/ml gave a partial inhibition of LTB4 generation, after LPS (1-100 ng/ml) treatment, while NDGA totally blocked the production of LTB4.”

“An inhibitor of the lipoxygenase pathway, nordihydroguaiaretic acid (NDGA), inhibited LTB4 production in a dose-dependent manner.”

“ Nordihydroguaiaretic acid (NDGA) (10 microM), used as a control, strongly inhibited the generation of LTB4.”

“The inhibitory effect of LTC4 but not that of LTB4 was abolished by FPL-55712, a LT antagonist; the enhanced colony growth induced by NDGA was reversed by both LTB4 and LTC4.”

“ LTB4 production by IL-1-activated neutrophils was suppressed by the lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and piriprost potassium [6,9,deepoxy-6,9-(phenylimino)-delta 6,8-prostaglandin l1], and a cyclooxygenase/lipoxygenase inhibitor, 5,8,11,14-eicosatetraynoic acid (ETYA), whereas a cyclooxygenase inhibitor, flurbiprofen, was inactive.”