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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Leukotriene B4
supplement:
Genistein
Research Papers that Mention the Interaction
“The anti-… effect of LTB4 was mimicked by 20,20,20-trifluoro-LTB4, LTB4-dimethylamide, and …,15-dehydro-LTB4, and was blunted by pertussis toxin and genistein , inhibitors of G alpha i GTP-binding proteins and tyrosine kinases, respectively, but not by staurosporine, 15(S)-HETE, or lipoxin A4.”
Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids.“The signaling induced by LTB4 did not seem to involve protein kinase C or A, but rather a tyrosine kinase, as suggested by its inhibition with genistein.”
“Further, we also found that genistein inhibited LTB4 production from A23187-stimulated cultures whereas H-7, a PKC inhibitor, had no effect on LTB4 production.”
“Further, genistein also inhibited leukotriene B4 production from A-23187 stimulated cultures.”
Inhibition of bovine mononuclear cell proliferation, interleukin-2 synthesis, protein-tyrosine kinase and leukotriene B4 production by a protein-tyrosine kinase inhibitor, genistein.“ Genistein , equol, quercetin, and kaempferol strongly inhibited LTB4 production without cytotoxicity.”
A new method to evaluate anti-allergic effect of food component by measuring leukotriene B4 from a mouse mast cell line
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