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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Leukotriene B4
supplement:
Eicosatrienoic Acid
Research Papers that Mention the Interaction
“The formation of LTB4 was dose dependently inhibited by both LA (IC50=45 μM) and DGLA (IC50=40μM).”
“The results show that the addition of LA and DGLA to neutrophils results in an inhibition of LTB4 formation and simultaneously to the formation of 13-HODE and 15-HETrE, that also inhibits LTB4 formation.”
Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophilsin vitro. Evidence of formation of antiinflammatory compounds“The inhibition of LTB4 formation by DGLA was associated with a dosedependent increase in its 15-LO metabolite 15-hydroxyeicosatrienoic acid (15-HETrE) and its CO metabolite prostaglandin E1 (PGE1).”
“These results show that the addition of DGLA to HPML results in a selective inhibition of LTB4 formation, presumably via its metabolite (15-HETrE).”
“Both 15-HETre and DGLA (provided exogenously) inhibited the formation of leukotriene B4 , (LTB4) and 20-hydroxy-leukotriene B4 (20-OH-LTB4).”
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