Possible Interaction: Leukotriene B4 and Ebselen

“In the present report we demonstrate that ebselen specifically inhibits the formation of LTB4 at lower concentrations than those at which it influences the production of 5-HPETE and LTA4.”

“ Ebselen , a new organoselenium compound with pronounced anti-inflammatory properties, selectively inhibits the formation of leukotriene B4 in human and porcine leukocytes with half-maximal inhibition at 4.0 and 2.7 mumol/1, respectively.”

“ Ebselen at 3–20 μM concentrations inhibited both chemotactic and chemokinetic responses to optimal concentrations of LTB4 without altering chemotactic responses to C5a or fMLP.”

“Both reactive oxygen species [24] and LTB4 [51, 52] enhance granulocyte adhesiveness to endothelium and ebselen inhibits the generation of reactive oxygen species, catalyses the breakdown of hydroperoxides, inactivates LTB4 by isomerization and inhibits 5-lipoxygenase [9–11, 13–16, 27–29].”

“In addition, ebselen also inactivates leukotriene B4 (LTB4) generated by pig leukocytes in vitro by isomerizing this eicosanoid to its biologically inactive 6-trans isomer.”

“When ethanolic extracts of the medium of stimulated cells were analysed by HPLC, a dose-dependent inhibition by ebselen of LTB4 formation with a concomitant decrease of 5-HETE production was found.”