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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Leucovorin and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

It has been shown that the administration of ascorbic acid to normal human subjects ingesting PGA caused a 3-fold increase in the amount of citrovorum factor (CF) excreted in the urine (4-6).
Nichol and Welch (8) reported that the formation of CF by slices of rat liver incubated in a medium containing PGA was augmented by the presence of ascorbic acid.
The Journal of biological chemistry  •  1953  |  View Paper
These results have been interpreted to indicate that ascorbic acid aids in the conversion of folic acid to CF.
The Journal of biological chemistry  •  1952  |  View Paper