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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Leucovorin and Methionine



Research Papers that Mention the Interaction

Since MET deprivation can individually potentiate the different chemotherapeutic agents used in the 48-hour combined regimen of 5-FU, leucovorin and oxaliplatin (FOLFOX) regimen, we initiated a feasibility study associating dietary MET restriction with the FOLFOX regimen in patients with metastatic colorectal cancer.
Oncology  •  2010  |  View Paper
Interestingly, FnA supplementation reduced intracellular AdoHcy levels only in cells grown under methionine restriction.
Nutrients  •  2018  |  View Paper
the addition of 5-formyltetrahydrofolate alone was ineffective in restoring formate oxidation, but it was effective when methionine was also added.
Biochemical pharmacology  •  1979  |  View Paper