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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Leucovorin
supplement:
Methionine
Research Papers that Mention the Interaction
“Since MET deprivation can individually potentiate the different chemotherapeutic agents used in the 48-hour combined regimen of 5-FU, leucovorin and oxaliplatin (FOLFOX) regimen, we initiated a feasibility study associating dietary MET restriction with the FOLFOX regimen in patients with metastatic colorectal cancer.”
Dietary Methionine Restriction with FOLFOX Regimen as First Line Therapy of Metastatic Colorectal Cancer: A Feasibility Study“Treatment with hydroxocobolamin, betaine, and folinic acid initiated at 28 hours of life lead to rapid reduction in plasma homocysteine and increased serum methionine concentrations.”
“Interestingly, FnA supplementation reduced intracellular AdoHcy levels only in cells grown under methionine restriction.”
“The combination of methionine exclusion and folinic acid addition lowered the FPGS activity to less than 25% that of control.”
Role of folylpolyglutamate synthetase in the regulation of methotrexate polyglutamate formation in H35 hepatoma cells.
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