Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Leucovorin and Levomefolate



Research Papers that Mention the Interaction

Folinic acid supplementation increased cerebrospinal fluid 5-MTHF levels, but with no objective evidence of clinical improvement.
In our double-blind randomized study, folinic acid supplementation resulted in increased 5-MTHF levels, but with no objective signs of clinical improvement.
Journal of child neurology  •  2012  |  View Paper
Uptake of 5-methyltetrahydrofolate was inhibited by structural analogs with the K(i) values being 0.50, 1.79, and 31.8 micro M for 5-formyltetrahydrofolate , methotrexate, and folic acid, respectively.
The Journal of nutritional biochemistry  •  2003  |  View Paper
Considering FA plus 5-MTHF together, the AUC (area under the curve) ratios between CSF and plasma were close to 1%.
British Journal of Cancer  •  1989  |  View Paper
The mechanism of folinic acid action in DHPR deficiency may be to increase indirectly the synthesis of 5-methyltetrahydrofolate.
The Journal of pediatrics  •  1987  |  View Paper
A small amount of CF entered the CSF, but peak CSF 5-MTHFA increased about 10-fold.
The concentration X time (… t) of additional 5-MTHFA in the CSF was greater [114.4 +/- 36.1 (S.E.) …/ml X min] after 100-mg/sq m doses of leucovorin than after 50 mg/sq m [14.2 +/- 4.… micrograms/ml X min] (p less than 0.05).
Cancer research  •  1983  |  View Paper
Prior incubation with 5-formyltetrahydrofolate increased uptake of [(14)C]5-methyltetrahydrofolate , and extracellular 5-formyltetrahydrofolate enhanced efflux of [(14)C]5-methyltetrahydrofolate.
The Journal of clinical investigation  •  1978  |  View Paper
Absorption with immobilized folinic acid markedly enhanced the specificity of this antiserum and resulted in a 15–20% increase in maximum inhibition by 5-MTHFA.
The assay using a later bleeding was more sensitive since 1.6 ng 5-MTHFA gave 50% inhibition (detection limit 0.2 ng), but folinic acid cross-reacted significantly.
Analytical biochemistry  •  1980  |  View Paper
Uptake of 5-FTHF was inhibited by the structural analogs 5-methyltetrahydrofolate , methotrexate and folic acid (K(i)=6.64, 7.69, and 19.38 microM, respectively).
Brain Research  •  2003  |  View Paper
Uptake of 5-FTHF was inhibited by the structural analogs 5-methyltetrahydrofolate , methtrexate, and folic acid (K(i)=3.8, 2.7, and 18.4 microM, respectively).
Archives of biochemistry and biophysics  •  2003  |  View Paper
Binding of 5-methyltetrahydrofolate was inhibited by methotrexate, folic acid, and 5-formyltetrahydrofolate , but not by glutamic acid, pteroic acid, or p-aminobenzoylglutamic acid.
NCI monographs : a publication of the National Cancer Institute  •  1987  |  View Paper
Show More