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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Leucovorin
supplement:
Levomefolate
Research Papers that Mention the Interaction
“ Folinic acid supplementation increased cerebrospinal fluid 5-MTHF levels, but with no objective evidence of clinical improvement.”
“In our double-blind randomized study, folinic acid supplementation resulted in increased 5-MTHF levels, but with no objective signs of clinical improvement.”
Folinic Acid Supplementation in Rett Syndrome Patients Does Not Influence the Course of the Disease: A Randomized Study“Uptake of 5-methyltetrahydrofolate was inhibited by structural analogs with the K(i) values being 0.50, 1.79, and 31.8 micro M for 5-formyltetrahydrofolate , methotrexate, and folic acid, respectively.”
“Considering FA plus 5-MTHF together, the AUC (area under the curve) ratios between CSF and plasma were close to 1%.”
“The mechanism of folinic acid action in DHPR deficiency may be to increase indirectly the synthesis of 5-methyltetrahydrofolate.”
“A small amount of CF entered the CSF, but peak CSF 5-MTHFA increased about 10-fold.”
“The concentration X time (… t) of additional 5-MTHFA in the CSF was greater [114.4 +/- 36.1 (S.E.) …/ml X min] after 100-mg/sq m doses of leucovorin than after 50 mg/sq m [14.2 +/- 4.… micrograms/ml X min] (p less than 0.05).”
“Prior incubation with 5-formyltetrahydrofolate increased uptake of [(14)C]5-methyltetrahydrofolate , and extracellular 5-formyltetrahydrofolate enhanced efflux of [(14)C]5-methyltetrahydrofolate.”
“Absorption with immobilized folinic acid markedly enhanced the specificity of this antiserum and resulted in a 15–20% increase in maximum inhibition by 5-MTHFA.”
“The assay using a later bleeding was more sensitive since 1.6 ng 5-MTHFA gave 50% inhibition (detection limit 0.2 ng), but folinic acid cross-reacted significantly.”
“Uptake of 5-FTHF was inhibited by the structural analogs 5-methyltetrahydrofolate , methotrexate and folic acid (K(i)=6.64, 7.69, and 19.38 microM, respectively).”
Transport of 5-formyltetrahydrofolate into primary cultured cerebellar granule cells“Uptake of 5-FTHF was inhibited by the structural analogs 5-methyltetrahydrofolate , methtrexate, and folic acid (K(i)=3.8, 2.7, and 18.4 microM, respectively).”
“Binding of 5-methyltetrahydrofolate was inhibited by methotrexate, folic acid, and 5-formyltetrahydrofolate , but not by glutamic acid, pteroic acid, or p-aminobenzoylglutamic acid.”
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