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Last Updated: 2 months ago

Possible Interaction: Leucovorin and Folate

supplement:

Folate

Research Papers that Mention the Interaction

Protocol B: Plasma folate increased significantly at four weeks in those receiving folinic acid (P = 0.0001) but tHcy was not significantly different between groups (P = 0.92).
Journal of nephrology  •  2003  |  View Paper
Concomitant folate supplementation with either folic or folinic acid decreases the plasma homocysteine level and consequently protects against potential cardiovascular risks.
Rheumatology  •  2002  |  View Paper
Based on pharmacokinetics at higher doses, steady-state total plasma reduced folate concentrations of 1 microM would be expected from the administration of leucovorin 50 mg/m2 by 24 h infusion.
Investigational new drugs  •  1995  |  View Paper
* Elevation of this reduced folate cofactor stabilizes the inhibitory ternary complex formed between the FU active metabolite, FdUMP and thymidylate … DNA synthesis or repair.1–4 It has been demonstrated both in animal models5 and in humans6 that administration of leucovorin results in intratumor elevation … closely related reduced folate, ….
Advances in experimental medicine and biology  •  1993  |  View Paper
ConclusionsThe expression level of FPGS, GGH and ABCC1 in CRC tissues could predict the reduced folate level after LV administration, and these factors may determine the efficacy of LV treatment.
Cancer Chemotherapy and Pharmacology  •  2009  |  View Paper
In primary tumor, only 200 and 500 mg/m2 FA resulted in a significant increase of reduced folates with highest values measured after 500 mg/m2 FA.
Clinical Cancer Research  •  2008  |  View Paper
Folinic acid enhances TS inhibition by increasing the intracellular pool of folates that stabilize the 5FU-TS complex.
Clinical and experimental pharmacology & physiology  •  1998  |  View Paper
folates increased about 2-fold in … lines after exposure to leucovorin (10 microM) for 4 h, and after a 6-hour efflux remained elevated (1.5- and 1.3-fold … levels) in RPMI-1788 and HT-1080 cells but decreased to 80% of control levels in HS-42 cells.
Cancer research  •  1992  |  View Paper
Serum folate levels for infants who took 0.64 to 1.7 mg leukovorin per kg ranged from 33 to 663 ng/ml.
Antimicrobial Agents and Chemotherapy  •  1992  |  View Paper
In vitro studies with human colon carcinoma (HCT-8) and renal carcinoma (SE) cells show that the increase of intracellular folate pools by LV is dose and time dependent and varies significantly between cell lines.
Seminars in oncology  •  1992  |  View Paper
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