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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Leucovorin
supplement:
Folate
Research Papers that Mention the Interaction
“Protocol B: Plasma folate increased significantly at four weeks in those receiving folinic acid (P = 0.0001) but tHcy was not significantly different between groups (P = 0.92).”
Controlled trials of very high dose folic acid, vitamins B12 and B6, intravenous folinic acid and serine for treatment of hyperhomocysteinemia in ESRD.“Concomitant folate supplementation with either folic or folinic acid decreases the plasma homocysteine level and consequently protects against potential cardiovascular risks.”
“Based on pharmacokinetics at higher doses, steady-state total plasma reduced folate concentrations of 1 microM would be expected from the administration of leucovorin 50 mg/m2 by 24 h infusion.”
“These studies reveal an increased stabilization of the 5-fluorodeoxyuridylate (FdUMP)-thymidylate synthase (TS) folate ternary complex with the addition of leucovorin.”
“In light of the demonstrated nondose-proportionality of total folates with oral leucovorin in this dose range, consideration should be given to parenteral administration in regimens employing higher doses.”
“ LV enhanced the anticancer activity of 5-FU and the level of reduced folate in human colon cancer cells.”
“Furthermore, when leucovorin was orally administered, the reduced folate levels in the tumors of mice fed a low folate diet were more than two-fold higher than those of mice fed the normal diet.”
“The remarkable increase in reduced folate levels following the administration of leucovorin contributed to the leucovorin-induced potentiation of TS-1 antitumor activity in this low-folate-diet animal model.”
“In primary tumor, only 200 and 500 mg/m2 FA resulted in a significant increase of reduced folates with highest values measured after 500 mg/m2 FA.”
“Infusion of 500 mg/m2 FA caused a significant increase of reduced folate levels in liver metastases.”
“There is abundant evidence that concomitant folate supplementation with either folic or folinic acid can reduce the incidence of MTX-related side-effects and allows for greater drug tolerability.”
“As little as 10 mg LV given orally can significantly raise the CNS folate level in only a few hours.”
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