Possible Interaction: Leucine and Verapamil

“An even better possibility is that verapamil may diminish necessary precursor molecule uptake into lymphocytes, since both the inactive and active isomeric forms of verapamil are capable of diminishing thymidine, uridine, and leucine incorporation into stimulated lymphocytes--necessary for DNA, RNA, and protein synthesis, respectively.”

“ConclusionIn a mouse heart model, ventricular ICa L before the weaning age (~21 days of age) exhibited a higher sensitivity to inhibition by verapamil than that after the weaning age, which may explain one possible mechanism associated with the development of verapamil-induced hypotension in human neonates and infants.”

“The action potential prolongation was shortened, the ICa L blocked and EAD suppressed by using verapamil (100 μmol/l) in the myocytes of MODS dogs (66%; 4 of 6).”

“They reported that L-type calcium current (ICa L ) blockade with verapamil shortened action potential duration and VT cycle length and likewise increased the stability of reentrant circuits.”

“Downregulation of α1c and β2A subunit expression and the resulting decay of ICa L current densities were prevented by verapamil.”

“Inhibiting the I(Ca L ) by verapamil resulted in significant (p<0.05 vs. control) decrease in systolic and diastolic blood pressure, PQ interval prolongation and slowing down of the sinus rate.”

“The L-type Ca2+ channel blockers verapamil and nifedipine inhibited NE-stimulated incorporation of [3H]leucine in myocytes and [3H]thymidine in fibroblasts, and these effects were not additive with those of ANP, SNAP, or 8-bromo-cGMP.”