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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Isoleucine (p = 0.017) and valine (p = 0.006) concentration decreased more in the leucine supplemented group than in placebo in A samples.”
Leucine supplementation does not enhance acute strength or running performance but affects serum amino acid concentration“The plasma concentrations of the keto acids of valine and isoleucine decreased by the leucine infusion while the concentrations of the keto acid of leucine and isoleucine decreased by glucose infusion.”
“Adding valine to the high leucine diet counteracted the feed intake reduction partially, while effects on daily gain and feed conversion ratio were largely counteracted by adding extra valine.”
Interaction between amino acids on the performances of individually housed piglets.“ Leucine and valine downregulated the expression of NPC1L1, ACC, FAS, SREBP-2, and HMGCR (P < 0.05).”
“Substitutions of leucine at position 492 with the hydrophobic amino acids valine or phenylalanine also reduced HDL endocytosis, stressing the importance of leucine at this position.”
“Molecular modeling predicted a rank order of (Val > Ile > Leu) that was verified experimentally with up to a ∼16-fold difference in binding affinity between a valine and a leucine in P(0).”
“Computational analysis suggests that conformational changes in the hydrophobic pocket occur when leucine is substituted for isoleucine or valine and that this change leads to susceptibility to pleconaril.”
“The difference in side chain size and orientation between valine and leucine affect the conformation of neighboring residues and “force” domain-1 into a different orientation (Fig. 1C, D).”
“Furthermore, the chlamydial growth inhibition induced by leucine , isoleucine, methionine, or phenylalanine was completely reversed by concomitant addition of valine.”
“Among the changes the postoperative decrease of VAL and LEU was significant.”
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