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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Leucine and Urea

supplement:

Leucine

drug:

Urea

Research Papers that Mention the Interaction

Urea clearance with 9 x 2 L was significantly greater than with the other three prescriptions (p < 0 0.05).
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis  •  2000  |  View Paper
The results show a significant (r2 = 0.691; p less than 0.0001) reduction of urea nitrogen production and proteolysis as a function of the increase in leucine dose.
Surgery  •  1991  |  View Paper
During continuous arteriovenous hemofiltration and continuous arteriovenous hemodialysis, a significant positive correlation was established between urea clearance and clearances of leucine (r2 = 0.953 and 0.927, respectively), isoleucine (r2 = 0.948 and 0.910, respectively), and valine (r2 = 0.953 and 0.864, respectively).
Pediatric Research  •  1994  |  View Paper
Although both leucine and energy supplementation reduced urinary urea excretion (P ≤ 0.02), treatments did not affect urea production (P ≥ 0.34) or urea recycling to the gut (P ≥ 0.30).
Journal of animal science  •  2012  |  View Paper
L-Leucine inhibits urea synthesis in rat hepatocytes from a number of nitrogen sources, including ammonia.
Biochimica et biophysica acta  •  1977  |  View Paper
With either alanine or a mixture of 15 different amino acids as nitrogen source, the addition of L-leucine inhibited the synthesis of urea by isolated rat liver cells.
The Biochemical journal  •  1975  |  View Paper
Urea at low concentrations reversibly suppresses the inhibitory effect of l -arginine and has no effect on enzyme activity.
Biochimica et biophysica acta  •  1967  |  View Paper