Possible Interaction: Leucine and Trypsin

“Pretreatment of AM with iodoacetic acid, trypsin , neuraminidase, or colchicine diminished attachment of L at 2 h. Neuraminidase pretreatment of L resulted in increased binding to nontreated AM.”

“… Leu …, trypsin , and chymotrypsin in the buffer and tissue, as well as the total activity (P < 0.05), especially at 0.40 and 0.80 mM. … had no effect on the tissue concentration of α-amylase, trypsin, and chymotrypsin or the total activity of α-amylase (P > 0.05).”

“The leucine supplementation increased α-amylase and trypsin activities and the messenger RNA expression of their coding genes (P <0.05), and it enhanced the mTOR synthesis and the phosphorylation of mTOR, ribosomal protein S6 kinase 1 and eukaryotic initiation factor 4E-binding protein 1 (P <0.05).”

“Deletion of CTSB reduced and deletion of cathepsin L increased intracellular trypsin activation.”

“Infusion of 10 g of leucine also increased the secretion rates (U/h) of trypsin , chymotrypsin, and lipase, but did not change their concentrations.”

“Further replacement of alanine by leucine reduces the rate for thrombin, but increases the binding for trypsin.”

“ Trypsin also stimulates reversion in L colonies growing on soft agar.”

“Toxin L is heat-labile, and its toxicity is reduced by trypsin and by phospholipase A treatment.”