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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
drug:
Troglitazone
Research Papers that Mention the Interaction
“We recently reported that troglitazone , an insulin-sensitizing agent, inhibited l-type Ca2+ current (ICa, L ) more effectively in streptozotocin (STZ)-induced diabetic ventricular myocytes than in age-matched control myocytes.”
Attenuated Inhibition of L-type Calcium Currents by Troglitazone in Fructose–Fed Rat Cardiac Ventricular Myocytes“Since troglitazone inhibits ICa, L more effectively in STZ‐induced diabetic ventricular myocytes, this agent may prevent cardiac dysfunction in diabetes.”
“ Troglitazone , an insulin‐sensitizing agent shown to improve cardiac function in both experimental animals and patients with diabetes, inhibits voltage‐dependent L‐type Ca2+ currents (ICa, L ) in cardiac myocytes, which may underlie its cardioprotective effects.”
“ [3H]Leucine uptake was also increased by mechanical strain (1.9-fold versus control, P <0.002), and this increase was inhibited by troglitazone and 15d-PGJ2 (troglitazone, −52% at 10 &mgr;mol/L, P <0.01; 15d-PGJ2, −70% at 10 &mgr;mol/L, P <0.005).”
“ Troglitazone effectively reduced the amplitude of ICa, L in a concentration-dependent manner.”
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