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Last Updated: 3 years ago

Possible Interaction: Leucine and Triiodothyronine

supplement:

Leucine

Research Papers that Mention the Interaction

Lysine appearance did not change during fasting or T3 supplementation, but leucine appearance decreased with T3 supplementation during fasting.
The Journal of clinical endocrinology and metabolism  •  1996  |  View Paper
The uptake of leucine , mediated by the amino acid transport system L, was inhibited by T3 and T4, and the nature of inhibition was competitive.
Endocrinology  •  1994  |  View Paper
Urinary excretion of 3‐methylhistidine and plasma concentrations of valine, methionine, lysine, tyrosine, phenylalanine, isoleucine, leucine , and total essential and branched chain amino acids increased following administration of T3 , probably in part reflecting accelerated muscle proteolysis.
European journal of clinical investigation  •  1986  |  View Paper
Moreover, the concentrations of Leu , Phe, and Arg were higher in T2 and T3 (P < 0.05).
Oxidative medicine and cellular longevity  •  2017  |  View Paper
Conversely, L-T3 inhibited the transport of [3H]leucine by pituitary cells (IC50 = 2 microM), but D-T3 and 3,5,3'-triiodothyroacetic acid (Triac) did not.
The Journal of biological chemistry  •  1993  |  View Paper
In this paper we have shown that T3 stimulates leucine uptake and incorporation into protein in primary cell cultures of neurons.
Endocrinology  •  1987  |  View Paper
The relative increase of T3 levels from comfortable to cold or hot environmental temperatures, was significantly higher in L and D animals (30 vs 12%, respectively).
Acta endocrinologica  •  1987  |  View Paper
After 6 to 48 hours, triiodothyronine induced a marked reduction in leucine uptake into the proteins of the gills, intestine, kidney, and tail.
The Journal of biological chemistry  •  1970  |  View Paper
T3 (10 μM) did not significantly trans stimulate L-[3H]phenylalanine efflux, but did competitively inhibit the trans stimulatory effect of 10 μM leucine.
Journal of thyroid research  •  2010  |  View Paper
Uptake of leucine , tyrosine, and tryptophan (10 M) was inhibited by the different iodothyronines (10 M), in particular T3.
Endocrinology  •  2001  |  View Paper