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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Leucine
drug:
Tolbutamide
Research Papers that Mention the Interaction
“… leucine to healthy subjects … chlorpropamide or tolbutamide (2, 3), and also to some patients with functioning islet cell tumors of the pancreas (4), increments in plasma leucine caused … insulin and decreases in blood glucose that were significantly greater than those observed in healthy subjects not pretreated with sulfonylurea drugs.”
Insulin secretion in response to protein ingestion.“Intraportal infusion of tolbutamide and leucine produced a greater fall in venous blood glucose than a doubled amount of tolbutamide alone.”
Hypoglycemia Due to Intrapancreatic Infusion of Leucine“Our studies have shown that tolbutamide can " sensitize " normal individuals to the hypoglycaemic effect of leucine , so it does appear that this is a general property of the sulphonylureas.”
“Since this study was begun Danowski et al. (1962) have shown that when leucine and tolbutamide are taken together the degree of hypoglycaemia is no greater than with tolbutamide alone, but the addition of leucine prolonged the duration of the hypoglycaemia.”
Acetohexamide in Treatment of Diabetes Mellitus
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