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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Leucine
drug:
Theophylline
Research Papers that Mention the Interaction
“ Theophylline or N6O2-dibutyryl- (db) cAMP at 1.6 mM glucose significantly increased the [3H]leucine incorporation.”
Biosynthesis of proinsulin and insulin in newborn rat pancreas. Interaction of glucose, cyclic AMP, somatostatin, and sulfonylureas on the (3H) leucine incorporation into immunoreactive insulin.“The results … showed that theophylline significantly improved the forced expiratory volume in 1 s, … and peak expiratory flow rate (WMD 0.09 L , 95%CI 0.09 - 0.09; WMD 0.14 L, 95%CI 0.…; WMD 17.0 L/min and 95%CI 6.9 - 27.2 respectively).”
“… theophylline experienced statistically fewer numbers [(0.8 +/- 1.2) times/year, (1.7 +/- 2.6) times/year, Z = -1.674, P = 0.047] and days … (n = 16, 3, Z = -2.198, P = 0.014), and that statistically greater improvement in pre-bronchodilators FEV(1) [(0.006 +/- 0.180) L, (-….”
“The review showed that theophylline significantly improved forced expiratory volume in 1 s and forced vital capacity (weighted mean difference 0.10 L ; 95% confidence interval 0.04–0.16 and weighted mean difference 0.21 L; 95% confidence interval 0.10–0.31, respectively).”
“Insulin secretion from freshly prepared tumour cells was not stimulated by glucose but was increased two-to threefold by leucine (20 mmol/l) plus theophylline (5 mmol/l).”
Glucocorticoids stimulate the division of rat pancreatic islet tumour cells in tissue culture“ Leucine (20mmol/l) plus theophylline (5 mmol/l) caused an abrupt, sustained and rapidly reversible stimulation of two- to fivefold.”
“The results indicated that theophylline administration leads to significantly higher concentrations of TC, FC, SC, L and AC in renal tissues as compared to those of control and placebo groups (P<0·001).”
“At … theophylline decreased significantly and half-life increased from 4.16 +/- 0.57 h (CG) to 7.08 +/- 0.… distribution volumes values of central (Vc) and peripheral (Vp) compartments (Vc: CG, 0.18 +/- 0.03 L ; HG, 0.24 +/- 0.03 L) (Vp: …; HG, 0.13 +/- 0.05 L).”
“ Theophylline , a drug that decreases the basolateral permeability to sugars, decreased the unidirectional influx of 1.25 mM leucine in Na+-free medium but increased the steady-state uptake of the aminoacid in Na+-medium.”
“The effect of leucine was weak, but was potentiated by a low concentration of glucose or by theophylline ; the effect of ketoisocaproate was stronger and faster than that of an equimolar concentration of glucose.”
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