Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 years ago

Possible Interaction: Leucine and Sunitinib

supplement:

Leucine

Research Papers that Mention the Interaction

Results indicate that sunitinib treatments prevent antiviral innate immune responses mediated by RNase L and PKR.
Sunitinib also impacts IRE1, an endoplasmic reticulum protein involved in the unfolded protein response that is closely related to RNase L. Here, we report that sunitinib is a potent inhibitor of both RNase L and PKR with IC50 values of 1.4 and 0.3 μm, respectively.
The Journal of Biological Chemistry  •  2011  |  View Paper
The ribonuclease activity of RNase L can be regulated by the kinase inhibitor sunitinib.
The Biochemical journal  •  2020  |  View Paper