“Results indicate that sunitinib treatments prevent antiviral innate immune responses mediated by RNase L and PKR.”
“Sunitinib also impacts IRE1, an endoplasmic reticulum protein involved in the unfolded protein response that is closely related to RNase L. Here, we report that sunitinib is a potent inhibitor of both RNase L and PKR with IC50 values of 1.4 and 0.3 μm, respectively.”